S-Nitrosoglutathione cytotoxicity toMycobacterium smegmatisand its use to isolate stationary phase survival mutants
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چکیده
منابع مشابه
Glutathione and S-nitrosoglutathione in alginate/chitosan nanoparticles: Cytotoxicity
Nitric oxide (NO) is involved in several physiological processes, such as the control of vascular tone, the immune response and the wound healing process. Thus, there is a great interest in the development of NO-releasing drugs and in matrices which are able to stabilize and release NO locally in different tissues. Thiols, such as glutathione (GSH), are ready nitrosated to form the NO donors S-...
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We extend Igusa ́s stationary phase method to the case of oscillatory integrals depending on several parameters. As a particular case, we obtain estimations for the modulus of Gaussian exponential sums depending on several parameters.
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Site-specific S-glutathionylation is emerging as a novel mechanism by which S-nitrosoglutathione (GSNO) may modify functionally important protein thiols. Here, we show that GSNO-Sepharose mimicks site-specific S-glutathionylation of the transcription factors c-Jun and p50 by free GSNO in vitro. Both c-Jun and p50 were found to bind to immobilized GSNO through the formation of a mixed disulphide...
متن کاملLocalization of S-nitrosoglutathione and expression of S-nitrosoglutathione reductase in pea plants under cadmium stress.
S-nitrosoglutathione (GSNO) is considered a natural nitric oxide (NO.) reservoir and a reactive nitrogen intermediate in animal cells, but little is known about this molecule and its metabolism in plant systems. In this work, using pea plants as a model system, the presence of GSNO in collenchyma cells was demonstrated by an immunohistochemical method. When pea plants were grown with a toxic Cd...
متن کاملRole of ergothioneine on S-nitrosoglutathione catabolism.
Ergothioneine (ESH) is a low-molecular-mass thiol present in millimolar concentrations in a limited number of tissues, including erythrocytes, kidney, seminal fluid and liver; however, its biological function is still unclear. In the present study we investigated the role of ESH in the catabolism of S-nitrosoglutathione (GSNO). The results show that: (1) GSNO decomposition is strongly influence...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2004
ISSN: 0378-1097,1574-6968
DOI: 10.1016/j.femsle.2004.08.030